cervical-cancer
Single-cell transcriptomic atlas of cervical cancer with PIK3CA mutations found a paradoxical TME: T-cell inflammation coexists with resistance to adaptive immune responses. PIK3CA-mutant epithelial cells induce CD8+ T cell exhaustion via both canonical PD-L1-PD-1 and non-canonical SPP1-CD44…
colorectal-cancer
scRNA-seq of primary CRC and liver metastases identified 5 CRC tumor cell subtypes. The C4 BCL2L1+ subset was predominantly enriched in liver metastases, showing enhanced proliferation, metabolic reprogramming, and anti-apoptotic activity. CEBPG regulates BCL2L1 expression; CEBPG silencing…
thyroid-cancer
Mendelian randomization showed a causal association between higher Terrisporobacter abundance and increased PTC risk (OR 2.06). In TCGA validation, higher Terrisporobacter correlated with immunosuppressive TME (more M2 macrophages, fewer CD8+ T cells) and NTRK1 upregulation (HR 2.15 for poor OS).…
blood-cancer
Systematic review of 29 phase 1-2 trials of non-engineered NK cell adoptive transfer in AML found: pooled 35% response rate in R/R AML (217 patients; 11 studies); 82% 1-year DFS in low-/intermediate-risk AML in remission; 40% 1-year DFS when combined with haploidentical HSCT. Toxicities were mild;…
thyroid-cancer
AI diagnostic system for thyroid nodules C-TIRADS ≥4A achieved excellent agreement with expert teleultrasound (kappa=0.80), vs. poor agreement between community institutions and teleultrasound (kappa=0.20). The AI achieved sensitivity of 97.1% and specificity of 100% at ≥C-TIRADS 4A threshold; AUC…
lung-cancer
Retrospective study of 73 NSCLC patients who didn't undergo surgery after neoadjuvant chemoimmunotherapy found no significant differences in PFS or OS between those who received radiotherapy vs. not. However, in patients with PET/CT SUVmax ≤4, RT did not improve PFS. For SUVmax ≥8, RT showed…
pancreatic-cancer
A series of ferrocene-pyrazole hybrid compounds were tested against pancreatic cancer (BxPC-3). Compound 11 showed superior anti-cancer effects and low toxicity to normal HK-2 cells, with low hemolytic activity. Proteomics and metabolomics revealed 35 proteins and 58 metabolites with significantly…
blood-cancer
AML harboring BCR::ABL1 is classified as adverse-risk by European LeukemiaNet guidelines, but this classification was established before TKIs were routinely added to treatment. This real-world study of 57 BCR::ABL1 AML patients from the Spanish PETHEMA registry assessed whether TKI addition changes…
prostate-cancer
This simulation study evaluated whether an AI system could autonomously diagnose a subset of prostate MRI examinations for clinically significant prostate cancer (csPCa), reserving uncertain cases for radiologists. Using data from 500 men across four European centers, AI thresholds were calibrated…
lung-cancer
In thermal ablation of lung tumors, adequate ablation margins (zone of destruction extending beyond the tumor) predict local tumor control. This study developed a 4-step lung-specific deformable image registration algorithm to accurately measure 3D ablation margins from pre- and post-procedural CT…
brain-cancer
Glioblastoma (GBM) remains one of the deadliest cancers with only 15-month median survival. Its immunosuppressive tumor microenvironment—shaped partly by prostaglandin E2 (PGE2) produced via the COX-2 pathway—severely limits immunotherapy efficacy.
bladder-cancer
BCG (Bacillus Calmette-Guérin) intravesical immunotherapy is the standard adjuvant treatment for non-muscle-invasive bladder cancer but has efficacy limitations and recurrence. This study tested whether melatonin could enhance BCG's anti-tumor effects in a murine bladder cancer model.
