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ImmunoComboDB: A Curated Database of CD4+ T Cell-Boosting + Checkpoint Inhibitor Combination Studies

ImmunoComboDB: A Curated Database of CD4+ T Cell-Boosting + Checkpoint Inhibitor Combination Studies An orally available small molecule (Alphataxin) that boosts tumor-infiltrating CD4+ T cells combined with anti-PD-1 achieved 37.5% objective response rate in colon cancer mice — significantly better than either monotherapy alone. Checkpoint immunotherapy response is frequently limited not

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MuxDx Planner: A Multiplex Antibody Panel Designer for Lung Cancer Diagnosis

MuxDx Planner: A Multiplex Antibody Panel Designer for Lung Cancer Diagnosis A single multiplexed antibody panel can now deliver comprehensive lung cancer diagnosis — tumor classification, biomarker assessment, and clinical features — from one tissue section, avoiding the tissue exhaustion that plagues sequential IHC testing. Designing a multiplexed antibody panel for cancer

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SCLC SubtypeTracker: Longitudinal Liquid Biopsy Subtype Monitor for Tarlatamab Patients

SCLC SubtypeTracker: Longitudinal Liquid Biopsy Subtype Monitor for Tarlatamab Patients SCLC transcription factor subtype (ASCL1, NEUROD1, POU2F3) can be inferred from circulating chromatin in blood, and treatment with tarlatamab can drive subtype switching as a resistance mechanism — making serial liquid biopsy monitoring clinically actionable. This research opens the door to

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StromalAtlas PDAC: An Interactive Single-Cell Fibroblast Subtype Browser for Pancreatic Cancer

StromalAtlas PDAC: An Interactive Single-Cell Fibroblast Subtype Browser for Pancreatic Cancer A single-cell RNA-seq study of 42 PDAC tumors identified an NFATC2-expressing CAF subpopulation associated with better survival — demonstrating that CAF heterogeneity in pancreatic cancer carries prognostic information that bulk analysis misses. The cancer-associated fibroblast field is exploding with single-cell

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SrcMatch: A Biomarker-to-Inhibitor Pairing Tool for Src-Driven Cancers

SrcMatch: A Biomarker-to-Inhibitor Pairing Tool for Src-Driven Cancers Six different Src inhibitors showed highly heterogeneous efficacy across OSCC cell lines, with sensitivity correlated to which oncogenic signaling pathways were active — suggesting that pathway activation profile, not just Src expression, should drive drug selection. The fundamental insight from this study is

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MetastaMap: Open Protocol + Data Repository for Ex Vivo Organ Invasion Studies

MetastaMap: Open Protocol + Data Repository for Ex Vivo Organ Invasion Studies Breast cancer cells preferentially invaded lung and liver ECM scaffolds but not intestinal scaffolds in the new ex vivo assay — perfectly matching clinical metastatic tropism patterns. The ex vivo invasion platform described in this paper fills a critical gap

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Cancer Equity Map: County-Level Socio-Behavioral Risk by Race and Cancer Type

Cancer Equity Map: County-Level Socio-Behavioral Risk by Race and Cancer Type High-mortality cancer counties within racial groups have distinct domain-specific socio-behavioral profiles — meaning effective cancer equity interventions need county-level, race-specific, domain-level targeting, not broad demographic averages. Build an interactive map of U.S. counties showing cancer mortality and socio-behavioral risk

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Thin Melanoma Recurrence Risk Calculator

Thin Melanoma Recurrence Risk Calculator Age >65, ulceration, and mitotic rate ≥1/mm² independently predict T1 melanoma recurrence within 2 years in the largest multi-site study of its kind — three factors any dermatologist already has at diagnosis. Build a simple, open-access clinical decision support calculator for thin (T1) melanoma

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PIES Score Calculator: Pancreatic Cancer Subtype from ctDNA Epigenomics

PIES Score Calculator: Pancreatic Cancer Subtype from ctDNA Epigenomics PIES (Pancreatic Integrated Epigenomic Score) can determine whether a patient's pancreatic cancer is classical or basal-like — predicting treatment response — from a blood draw, without biopsy. Build an open-source implementation of the PIES scoring pipeline that takes cfDNA epigenomic profiling

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BF-BOLD Trial Simulator: Interactive Phase I Dose-Finding Tool

BF-BOLD Trial Simulator: Interactive Phase I Dose-Finding Tool The BF-BOLD design improves safety and activity assessment in Phase I trials without complex statistical modeling — but adoption requires trial teams to understand and simulate the design before committing to it. Build an open-source, browser-based simulator for the BF-BOLD (and comparison BOLD/

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GBM Recurrence Resistance Tracker: Open Registry for Matched Tumor Models

GBM Recurrence Resistance Tracker: Open Registry for Matched Tumor Models The 'resistant GSC families' platform generates within-patient matched models of chemo vs. radiation resistance from the same tumor — but there's no shared registry where labs can pool and compare these models across institutions. Build an open

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GBM Subtype Classifier + Targeted Therapy Recommender

GBM Subtype Classifier + Targeted Therapy Recommender HVEM is selectively expressed in mesenchymal GBM, and its inhibition hits both direct tumor growth and immune evasion via BTLA — but only in the mesenchymal subtype, making subtype identification clinically critical. Build a lightweight GBM molecular subtype classifier that takes RNA-seq or NanoString expression