lung-cancer
Low-dose CT lung cancer screening frequently detects incidental findings beyond lung nodules. This study found that significant incidental findings on screening CT were associated with an increased risk of being diagnosed with a non-lung cancer (extrapulmonary cancer) within the following year.
lung-cancer
A 58-year-old man with lung adenocarcinoma who had received neoadjuvant tislelizumab + carboplatin + docetaxel developed severe concurrent drug-induced liver injury (DILI) and toxic epidermal necrolysis (TEN) 10 days after starting moxifloxacin for pneumonia. Moxifloxacin was the probable causative…
lung-cancer
Retrospective study of 73 NSCLC patients who didn't undergo surgery after neoadjuvant chemoimmunotherapy found no significant differences in PFS or OS between those who received radiotherapy vs. not. However, in patients with PET/CT SUVmax ≤4, RT did not improve PFS. For SUVmax ≥8, RT showed…
lung-cancer
In thermal ablation of lung tumors, adequate ablation margins (zone of destruction extending beyond the tumor) predict local tumor control. This study developed a 4-step lung-specific deformable image registration algorithm to accurately measure 3D ablation margins from pre- and post-procedural CT…
lung-cancer
This population-based case-control study from Northern Ireland is the first UK study to link a nationwide indicative radon atlas with lung cancer risk. 1,687 lung cancer cases (2006, 2014) were compared to 8,094 controls, with radon exposure classified by an atlas categorizing 1 km² areas.
lung-cancer
Analysis of 421 SCLC patients at Karolinska using Bayesian and competing risk models: neutropenia during first-line treatment associated with better OS (HR 0.70). Higher etoposide dose linked to more AEs. Dose adjustment did not affect OS if patients completed 4 cycles. Male patients had fewer AEs…
lung-cancer
BDH2 overexpression in LUAD cell lines and xenograft mice significantly inhibited migration, invasion, and metastasis. Mechanism: BDH2 suppresses the Nrf2/HO-1 ferroptosis-resistance pathway, enhancing cancer cell sensitivity to ferroptotic death. Ferroptosis inhibitor Fer-1 reversed these effects,…
lung-cancer
17 metastatic lung cancer and melanoma treatment responders who received CALM therapy described their experience. Four themes emerged: twilight zone between illness/health, ongoing uncertainty, struggling to adapt, and shift over time. CALM was valued for safe processing space, addressing…
lung-cancer
NSCLC patients with COPD respond better to anti-PD-1 immunotherapy. COPD-driven epithelial remodeling expands CXCL14+ basal-like tumor cells, which recruit CXCL9+ macrophages via CXCL14-CXCR4 signaling, amplifying cytotoxic T cell infiltration. This tumor-macrophage axis predicts pathological…
lung-cancer
Cancer cachexia is common in NSCLC patients receiving immunotherapy and predicts poor outcomes. Western diagnostic criteria (Fearon) may miss cachexia in Asian patients with lower baseline body mass. In 411 Japanese PD-L1-high NSCLC patients, 40.9% were cachectic by Asian Working Group for Cachexia…
lung-cancer
Low-dose CT scans for lung cancer screening frequently detect incidental findings — abnormalities not related to the lungs. This retrospective cohort study found that significant incidental findings on lung screening CT were associated with a substantially increased risk of being diagnosed with a…
colorectal-cancer
This news roundup covers two cancer-relevant items. First, the Physicians Committee for Responsible Medicine petitioned the USDA to require colon cancer warning labels on processed meats and poultry — similar to how alcohol carries cancer warnings. Processed meats are classified as Group 1…