lung-cancer
Delta-like ligand 3 (DLL3) is a protein selectively expressed on small cell lung cancer (SCLC) cells — and virtually not on normal adult tissue — making it an ideal cancer target. DLL3-targeting therapies are already showing clinical benefit, but understanding what controls DLL3 expression could…
brain-cancer
Diffuse midline glioma (DMG) is one of the most devastating childhood brain cancers, with almost no effective treatments. This study investigated how neurotransmitter signaling and epigenetic mechanisms might be targeted in combination to fight this cancer.
blood-cancer
Myelofibrosis (MF) is the most severe type of myeloproliferative neoplasm, characterized by scarring of the bone marrow that eventually destroys normal blood cell production. Current treatments rarely reverse this fibrosis, and progress has been hampered by a lack of good animal models.
lung-cancer
BRCA1 and BRCA2 are well-known cancer genes in breast and ovarian cancer, but their role in lung cancer is less understood. This study used single-cell sequencing and multi-omics data to characterize how BRCA1/2 mutations reshape the tumor microenvironment in lung adenocarcinoma (LUAD).
breast-cancer
Before a cancer fully forms, cells go through a preneoplastic phase — a kind of 'almost cancer' state. A new study reveals that tunneling nanotubes (TNTs), thin actin-rich tubes that cells use to communicate over long distances, play a surprising role in this early transformation of breast tissue.
blood-cancer
Acute myeloid leukemia (AML) is notoriously hard to treat partly because leukemic stem cells — the root source of the disease — can develop resistance to therapies. This study investigated whether these stem cells depend on PI3 kinase (PI3K), a key cell-signaling enzyme. Researchers found that…
project-idea
AR-Status Dashboard: Androgen Receptor Pathway Deactivation Tracker for Prostate Cancer Loss of canonical AR signaling correlates with prostate cancer progression, raising the concern that androgen deprivation therapy may paradoxically promote escape in tumors where AR is already deactivated. Build a clinical evidence aggregator and visualization dashboard that synthesizes published data
project-idea
ProteostasisVuln: A Cancer Proteostasis Vulnerability Screener Cancer cells with low HSF1 expression become catastrophically sensitive to mTORC1 reactivation, creating a potential synthetic lethality. This selective vulnerability does not exist in normal cells, suggesting it could be mapped across many cancer types. Build an open bioinformatics tool that cross-references public tumor
prostate-cancer
Blocking sex hormone signaling can paradoxically fuel prostate cancer escape, a fly model reveals. Androgen deprivation therapy — suppressing male sex hormone signaling — is a cornerstone of advanced prostate cancer treatment. The underlying assumption is that prostate cancers depend on androgen receptor (AR) signaling to survive. But this study challenges that
sarcoma
Overloading cancer cells’ protein quality control triggers self-destruction — a new strategy for hard-to-treat tumors. Every living cell carefully balances its protein inventory: too many misfolded or aggregated proteins spell disaster. Heat shock factor 1 (HSF1) acts as a master emergency manager, cleaning up protein damage under stress. Cancers exploit HSF1
project-idea
ChemoSense TNBC: A Pre-Treatment Biomarker Screener for Triple-Negative Breast Cancer Chemoresistance Pre-treatment biopsies from TNBC patients show distinct proteomic and metabolomic signatures — particularly SIRT5 overexpression — that predict de novo chemoresistance before a single dose of treatment is given. The ability to predict chemotherapy resistance before treatment starts is one of
project-idea
PedBrainTarget: A Drug-Target Interaction Tracker for Pediatric Brain Cancer Stem Cell Pathways A REST-AKT-SOX2 regulatory axis maintains therapy-resistant stem/progenitor cells in Sonic Hedgehog medulloblastoma — and both AKT inhibitors and Midkine inhibitors with clinical-stage compounds already exist. Pediatric brain tumors are difficult to treat partly because of the disconnect between
