brain-cancer
Territory-wide retrospective cohort of 274 pediatric brain tumor survivors found ADHD in 10.6% and ASD in 6.9%—significantly above general population rates. Risk factors: younger age at diagnosis, seizure history, supratentorial location, radiotherapy. Better sleep quality correlated with fewer…
prostate-cancer
The CALLY index (derived from CRP, albumin, lymphocyte count—all from routine blood tests) was tested in 192 mHSPC patients. High CALLY patients had 71% lower all-cause mortality risk (HR 0.29) and 49% lower CRPC progression risk (HR 0.51), consistent across subgroups.
breast-cancer
Analysis of 4,400+ breast cancer patients found women under 50 with grade 1 tumors ≤1 cm and no LVI had just 4.92% lymph node metastasis rate—nearly identical to the 5.95% in women ≥50 with the same features. Age alone does not determine nodal risk in low-risk breast cancer.
brain-cancer
EA-Net uses edge attention combining Multi-Scale Context Fusion and Edge Segmentation modules to improve brain tumor boundary detection. Achieved Dice coefficients of 90.37% for Tumor Core and 88.91% for Whole Tumor on BraTS2021, with strong cross-dataset generalization.
pancreatic-cancer
Alkaliptosis is a pH-dependent cell death mechanism driven by JTC801 that disrupts intracellular pH homeostasis. Because it is mechanistically distinct from apoptosis, cells resistant to standard treatments remain susceptible. Particularly effective against pancreatic ductal adenocarcinoma. This…
blood-cancer
This protocol describes using CRISPR-Cas9 knockout screens to systematically identify genes mediating drug resistance in AML. Cells surviving better when a particular gene is deleted implicate that gene in resistance to cytarabine or venetoclax.
blood-cancer
An optofluidic chip using laser light scatter patterns and SVM machine learning classified drug-resistant vs drug-sensitive leukemia cells with 91.1% accuracy in about 20 minutes. The label-free method requires no staining, making it practical for rapid clinical diagnostics.
pancreatic-cancer
CECMS combines CbAgo (which eliminates wild-type DNA) with CRISPR-Cas12a (which detects enriched mutant alleles) to achieve 100-fold higher sensitivity than conventional Cas12a biosensors, detecting VAFs as low as 0.01%. In undiluted human serum, it detected KRAS G12D mutations at 0.1% VAF.
thyroid-cancer
In a SEER database study of 916,151 men, those with both thyroid and prostate cancer had lower all-cause and cancer-specific mortality than men with either cancer alone. TC+PC patients had 22% lower all-cause mortality and 42% lower TC-specific mortality vs TC-only, and 17% lower all-cause…
pancreatic-cancer
Follow-up of 35 patients with serous cystadenomas over 32 months found no malignant transformation and no association between initial lesion size and subsequent growth rate. Both large (>4 cm) and small SCAs grew equally, challenging the ACR recommendation for surgical consultation in large…
cervical-cancer
Interviews with Islamic leaders from 5 traditions in Bangladesh found HPV vaccine support was influenced by limited cervical cancer awareness, safety concerns, fears of promoting promiscuity, and critically—political ideology. Leaders from traditions feeling politically marginalized by the…
colorectal-cancer
Pyroptosis, a gasdermin-driven inflammatory cell death, can promote CRC via chronic inflammation and immunosuppressive TME, or suppress tumors through direct cancer cell killing and anti-tumor immunity activation. This review synthesizes molecular mechanisms, pathway crosstalk (apoptosis,…
