brain-cancer

Children who survive brain tumors face dramatically elevated rates of ADHD and autism—sleep may help.

Territory-wide retrospective cohort of 274 pediatric brain tumor survivors found ADHD in 10.6% and ASD in 6.9%—significantly above general population rates. Risk factors: younger age at diagnosis, seizure history, supratentorial location, radiotherapy. Better sleep quality correlated with fewer…

Children who survive brain tumors face dramatically elevated rates of ADHD and autism—sleep may help.

Key Findings

ADHD: 10.6%; ASD: 6.9%—significantly above population rates
Younger diagnosis age, seizures, supratentorial tumors predicted worse outcomes
Radiotherapy associated with reduced quality of life
Better sleep correlated with fewer ADHD symptoms

Implications

Survivorship programs should include routine neurobehavioral screening and sleep assessment. Sleep interventions may improve outcomes.

Caveats

Retrospective Hong Kong cohort; abstract-only. Parental reporting bias possible. Cross-sectional design limits longitudinal conclusions.

Source: Journal of neuro-oncology — 2026-04-11

Landmark DCIS trial, CRC microbiome & AML combos

Two themes cut across this week’s 236 posts. The first is de-escalation: researchers are building rigorous evidence that patients can safely do less — skip lymph node surgery, forgo radiotherapy, watch pre-invasive lesions instead of cutting them out. The landmark result here is a randomized trial confirming that active surveillance

Colorectal Cancer Microbiome Discovery Platform

Analysis of 9,000+ patients revealed that only colorectal cancer — not other cancer types — consistently harbors distinct microbial communities, suggesting the gut microbiome has a unique relationship with colorectal carcinogenesis that could be exploited for diagnostics and treatment.

GBM Tumor Microenvironment Drug Target Atlas

Non-cancerous brain support cells were found to promote glioblastoma growth through paracrine signaling, and blocking this communication dramatically slowed tumor growth — revealing that GBM's microenvironment contains targetable vulnerabilities that are being systematically overlooked by drug…

BET Inhibitor Target Selectivity Database

BRD2 and BRD4 have fundamentally distinct functions — BRD2 prepares genes for activation while BRD4 triggers transcription — meaning that pan-BET inhibitors have been disrupting gene regulation in counterproductive ways, and the field now needs selective BRD4 inhibitors.

Children who survive brain tumors face dramatically elevated rates of ADHD and autism—sleep may help.

Key Findings

Implications

Caveats

Read more

Landmark DCIS trial, CRC microbiome & AML combos

Colorectal Cancer Microbiome Discovery Platform

GBM Tumor Microenvironment Drug Target Atlas

BET Inhibitor Target Selectivity Database