thyroid-cancer
Epithelial-mesenchymal transition (EMT) enables cancer cells to become invasive and metastasize. This study used single-cell RNA sequencing combined with 101 machine learning algorithm combinations to build an EMT-based prognostic model for papillary thyroid carcinoma (PTC).
thyroid-cancer
Mendelian randomization showed a causal association between higher Terrisporobacter abundance and increased PTC risk (OR 2.06). In TCGA validation, higher Terrisporobacter correlated with immunosuppressive TME (more M2 macrophages, fewer CD8+ T cells) and NTRK1 upregulation (HR 2.15 for poor OS).…
thyroid-cancer
AI diagnostic system for thyroid nodules C-TIRADS ≥4A achieved excellent agreement with expert teleultrasound (kappa=0.80), vs. poor agreement between community institutions and teleultrasound (kappa=0.20). The AI achieved sensitivity of 97.1% and specificity of 100% at ≥C-TIRADS 4A threshold; AUC…
thyroid-cancer
MEN2B is a genetic syndrome caused by the RET p.M918T mutation requiring prophylactic thyroidectomy within the first year of life. This single-center study of 6 children with sporadic MEN2B found that despite exhibiting the complete, distinctive phenotype (marfanoid habitus, mucosal neuromas,…
thyroid-cancer
In a SEER database study of 916,151 men, those with both thyroid and prostate cancer had lower all-cause and cancer-specific mortality than men with either cancer alone. TC+PC patients had 22% lower all-cause mortality and 42% lower TC-specific mortality vs TC-only, and 17% lower all-cause…