prostate-cancer
This systematic review and meta-analysis found that pre-treatment MRI in men undergoing radical prostatectomy provides independent prognostic value for oncological outcomes beyond standard clinical and pathological staging. MRI can assess extracapsular extension, seminal vesicle invasion, and lymph…
prostate-cancer
Meta-analysis of 8 studies (6 RCTs, 2 cohort studies; n=18,456 patients) found ADT + RT significantly improved OS (HR 0.75), PFS (HR 0.41), and PSM (HR 0.52) compared to ADT alone. Subgroup analysis showed greatest benefit in locally advanced or node-positive disease. However, combination…
prostate-cancer
This simulation study evaluated whether an AI system could autonomously diagnose a subset of prostate MRI examinations for clinically significant prostate cancer (csPCa), reserving uncertain cases for radiologists. Using data from 500 men across four European centers, AI thresholds were calibrated…
prostate-cancer
The CALLY index (derived from CRP, albumin, lymphocyte count—all from routine blood tests) was tested in 192 mHSPC patients. High CALLY patients had 71% lower all-cause mortality risk (HR 0.29) and 49% lower CRPC progression risk (HR 0.51), consistent across subgroups.
thyroid-cancer
In a SEER database study of 916,151 men, those with both thyroid and prostate cancer had lower all-cause and cancer-specific mortality than men with either cancer alone. TC+PC patients had 22% lower all-cause mortality and 42% lower TC-specific mortality vs TC-only, and 17% lower all-cause…
prostate-cancer
Pre-treatment multiparametric MRI is increasingly used to characterize prostate cancer before surgery. This systematic review and meta-analysis of 40 studies investigated whether MRI-detected features provide independent prognostic value for oncologic outcomes in men undergoing radical…
prostate-cancer
Blocking sex hormone signaling can paradoxically fuel prostate cancer escape, a fly model reveals. Androgen deprivation therapy — suppressing male sex hormone signaling — is a cornerstone of advanced prostate cancer treatment. The underlying assumption is that prostate cancers depend on androgen receptor (AR) signaling to survive. But this study challenges that
breast-cancer
High-mortality cancer counties within racial groups have distinct socioeconomic profiles — not just worse averages of the same problems Racial disparities in breast and prostate cancer mortality are well documented at the population level, but this hides important variation within racial and ethnic groups. A county in which Black women have