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Cell Cycle Phase–Invasion Window Simulator for Metastasis Research Invadopodia-mediated invasion is cell cycle phase-dependent and shifts as EMT progresses — meaning the window when a cancer cell is most invasive can be predicted based on its EMT state. Build an interactive educational and research tool that visualizes the relationship between
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Tumor Board Prep Assistant: LLM-Powered Variant Briefing Generator The CIViC MCP server enables natural language queries to expert-curated cancer variant interpretations — meaning clinicians can now ask plain-English questions and get synthesized answers about a patient's tumor mutations. Build a clinical workflow tool that takes a patient's
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Spliceosome Disruption Atlas: Natural Compounds × Cancer Crocin (from saffron) consistently downregulates spliceosomal machinery genes across all time points in liver cancer cells — a mechanism relevant to over 90% of cancers, yet largely untargeted by approved drugs. Build a curated, searchable database of natural compounds with documented effects on spliceosome machinery
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RB1-Loss Drug Repurposing Navigator for DLBCL GAK inhibition is tumor-selective in RB1-deficient DLBCL, and OTS167 — already in human trials for solid tumors — potently hits GAK. This opens a rapid repurposing path gated on a single biomarker. Build a web tool that maps approved and late-stage investigational drugs to their off-target