other-cancer
BET inhibitors (targeting BRD2 and BRD4 proteins) have shown promise in cancer research but frequently disappointing results in clinical trials. This study reveals that BRD2 and BRD4 have distinct, non-overlapping functions. Current BET inhibitors that block both simultaneously may disrupt cellular…
other-cancer
Zeaxanthin, a carotenoid nutrient found in leafy greens and egg yolks and commonly taken for eye health, has been found to strengthen T cells and enhance the impact of cancer immunotherapy treatments in a preclinical study. The mechanism involves improved T cell metabolic fitness and anti-tumor…
other-cancer
Obesity is a major cancer risk factor and also impairs survival after diagnosis. This expert commentary calls for integrating the most effective obesity treatments—bariatric surgery and GLP-1 receptor agonists (like semaglutide/Ozempic)—into standard cancer survivorship care.
other-cancer
While the HPV vaccine has been well-established in women, evidence for cancer protection in males has been more limited. This large retrospective cohort study found that the 9-valent HPV vaccine was associated with significantly lower risk of HPV-related cancers in adolescent males and young men.
other-cancer
Oral squamous cell carcinoma (OSCC) is the most common oral malignancy, and Notch signaling is frequently altered in it. Using transgenic animal models, advanced imaging, and next-generation sequencing, this study mapped Notch pathway dysregulation in OSCC development and progression.
blood-cancer
BET inhibitors (drugs targeting BET bromodomain proteins) showed extraordinary promise in early cancer research — they could suppress the expression of potent oncogenes like MYC. But clinical trials have repeatedly disappointed, with patients not responding as expected. A new study may have found…
other-cancer
Zeaxanthin is a carotenoid (pigment) found in yellow vegetables like corn and kale and commonly taken as an eye health supplement. A new study found that zeaxanthin also has potent effects on immune cells — specifically, it strengthens T cell function and enhances the effectiveness of cancer…
lung-cancer
Low-dose CT scans for lung cancer screening frequently detect incidental findings — abnormalities not related to the lungs. This retrospective cohort study found that significant incidental findings on lung screening CT were associated with a substantially increased risk of being diagnosed with a…
other-cancer
Obesity is an established risk factor for at least 13 types of cancer and worsens outcomes for cancer survivors. Despite this, most cancer care doesn't include systematic obesity management. A commentary from obesity and oncology specialists argues that the explosion of effective obesity treatments…
cervical-cancer
While the HPV vaccine has long been established as protective against cervical cancer in women, its benefits for males have been less clearly documented at the population level. This large retrospective cohort study examined HPV-related cancer incidence in males ages 9 to 26 who received the…
other-cancer
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary syndrome associated with aggressive neuroendocrine tumors, including gastrinomas — tumors arising from the duodenum that cause excess gastrin production. While MEN1 is a well-known tumor suppressor gene, many duodenal gastrinomas retain a…
other-cancer
Appendiceal adenocarcinoma (AA) is a rare cancer with very limited treatment options. KRAS is the most commonly mutated gene in AA, making KRAS inhibitors a logical therapeutic target, but no preclinical or clinical data existed for this cancer type.