other-cancer
While the HPV vaccine has been well-established in women, evidence for cancer protection in males has been more limited. This large retrospective cohort study found that the 9-valent HPV vaccine was associated with significantly lower risk of HPV-related cancers in adolescent males and young men.
cervical-cancer
Three-dimensional image-guided brachytherapy (3D-IGBT) for cervical and endometrial cancer requires precise contouring of organs at risk (OARs: bladder, small bowel, rectum, sigmoid) for treatment planning. Manual contouring is time-consuming and variable. This study developed and tested a deep…
cervical-cancer
Single-cell transcriptomic atlas of cervical cancer with PIK3CA mutations found a paradoxical TME: T-cell inflammation coexists with resistance to adaptive immune responses. PIK3CA-mutant epithelial cells induce CD8+ T cell exhaustion via both canonical PD-L1-PD-1 and non-canonical SPP1-CD44…
cervical-cancer
HPV genotyping of 429 cervical swabs from Northeast India found 17.25% positivity. Among positives, HPV-16 was 52.70%, HPV-59 was 13.51%, HPV-18 was 8.10%, and HPV-58 was 5.4%. HPV-58 positive women showed cytological abnormalities; one HPV-59 case had poorly differentiated malignancy. Standard…
cervical-cancer
Single-cell RNA and TCR sequencing on paired tumor core and edge samples from 13 cervical squamous cell carcinoma patients found tumor cores had higher T cell exhaustion. Four exhausted CD8+ T cell subsets were identified; a stress-associated HSP-expressing subset inversely correlated with survival…
cervical-cancer
Interviews with Islamic leaders from 5 traditions in Bangladesh found HPV vaccine support was influenced by limited cervical cancer awareness, safety concerns, fears of promoting promiscuity, and critically—political ideology. Leaders from traditions feeling politically marginalized by the…
cervical-cancer
Survey of 250 Indigenous women in rural Nepal found only 18% knew one prevention behavior for cervical cancer, yet 76.8% were positive toward screening and 81.6% toward HPV vaccination. The barrier is information, not willingness. Culturally tailored health education programs are urgently needed.
cervical-cancer
While the HPV vaccine has long been established as protective against cervical cancer in women, its benefits for males have been less clearly documented at the population level. This large retrospective cohort study examined HPV-related cancer incidence in males ages 9 to 26 who received the…
cervical-cancer
Human papillomavirus (HPV) causes cervical cancer mainly through its E7 oncoprotein, which disables the tumor suppressor Rb. Previous research showed E7 can increase levels of LASP1 — a protein that promotes cancer cell proliferation and invasion — by suppressing a microRNA that normally limits…