breast-cancer
Multiple versions of a single RNA molecule control cancer cell division and p53 signaling in distinct ways Long non-coding RNAs (lncRNAs) don't encode proteins but profoundly shape gene regulation, and many are highly expressed in aggressive cancers. MANCR is one such lncRNA, highly active in triple-negative breast cancer
breast-cancer
Obesity-driven fat cell signals reshape triple-negative breast cancer's metabolism and gene activity to boost survival Obesity significantly increases triple-negative breast cancer (TNBC) risk and worsens outcomes, but the molecular mechanisms have been unclear. This study examined how signals secreted by fat cells (the adipocyte secretome) reprogram TNBC cells
breast-cancer
New lab platform mimics how breast cancer cells choose which organs to invade Researchers have developed an ex vivo invasion assay that uses real mouse organ tissue — lungs, liver, and intestine — stripped of cells but with the extracellular matrix (ECM) intact, then sliced and loaded into microfluidic channels. Cancer cells
breast-cancer
High-mortality cancer counties within racial groups have distinct socioeconomic profiles — not just worse averages of the same problems Racial disparities in breast and prostate cancer mortality are well documented at the population level, but this hides important variation within racial and ethnic groups. A county in which Black women have
breast-cancer
Protein FILIP1L acts as a metastasis coordinator in breast cancer, linking cell division timing to invasive behavior Cancer cells invade surrounding tissue using specialized structures called invadopodia — spiky protrusions armed with enzymes that chew through the extracellular matrix. Researchers discovered that when breast cancer cells undergo epithelial-to-mesenchymal transition (EMT, the