cervical-cancer
While the HPV vaccine has long been established as protective against cervical cancer in women, its benefits for males have been less clearly documented at the population level. This large retrospective cohort study examined HPV-related cancer incidence in males ages 9 to 26 who received the…
pancreatic-cancer
CA19-9 is the most commonly used blood biomarker for pancreatic cancer, elevated in most patients and used to monitor disease progression. But this study reveals that CA19-9 isn't merely a passive indicator — it actively promotes liver metastasis.
lung-cancer
Lung squamous cell carcinoma (LUSC) is a major lung cancer subtype with limited treatment options and poor outcomes. A key challenge in developing new therapies is the lack of preclinical models that accurately represent the tumor's histological complexity, including keratinizing morphology — a…
lung-cancer
FOXA1 is a 'pioneer' transcription factor that helps establish and maintain the identity of epithelial cells. In early-stage lung adenocarcinoma, FOXA1 keeps cells organized and polarized. This study investigated what happens when FOXA1 function is partially lost.
brain-cancer
Glioblastoma (GBM) is the most lethal brain tumor, notorious for resisting treatment. A major reason is intratumoral heterogeneity — different parts of the tumor can be biologically distinct. This study directly characterized this heterogeneity by taking multiple MRI-guided biopsies from different…
liver-cancer
A remarkable and unexpected finding: antibodies that people make against common enteroviruses (like rhinoviruses that cause colds) may cross-react with liver cancer cells, providing a measure of natural immune protection against hepatocellular carcinoma (HCC).
melanoma
Oncolytic viruses — engineered viruses that preferentially infect and kill cancer cells — are a promising cancer immunotherapy approach. When injected directly into a tumor, they can sometimes trigger shrinkage of distant, uninjected tumors as well. But exactly how this 'abscopal' effect works at…
pancreatic-cancer
Pancreatic ductal adenocarcinoma (PDAC) is typically stratified into 'basal-like' and 'classical' molecular subtypes, which carry different prognoses. But histological morphology — what the tumor looks like under a microscope — also varies significantly and may carry independent information.
other-cancer
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary syndrome associated with aggressive neuroendocrine tumors, including gastrinomas — tumors arising from the duodenum that cause excess gastrin production. While MEN1 is a well-known tumor suppressor gene, many duodenal gastrinomas retain a…
other-cancer
Appendiceal adenocarcinoma (AA) is a rare cancer with very limited treatment options. KRAS is the most commonly mutated gene in AA, making KRAS inhibitors a logical therapeutic target, but no preclinical or clinical data existed for this cancer type.
cervical-cancer
Human papillomavirus (HPV) causes cervical cancer mainly through its E7 oncoprotein, which disables the tumor suppressor Rb. Previous research showed E7 can increase levels of LASP1 — a protein that promotes cancer cell proliferation and invasion — by suppressing a microRNA that normally limits…
other-cancer
Neuroblastoma and paraganglioma are both cancers arising from the sympathoadrenal lineage (cells near the adrenal gland), yet they can appear quite different. How they're related developmentally and why they're so heterogeneous has been unclear.