colorectal-cancer
Arginine deiminase (ADI) depletes arginine—an amino acid many cancer cells cannot synthesize themselves. This study tested a recombinant ADI from the probiotic bacterium Limosilactobacillus reuteri against HCT116 colorectal cancer cells.
thyroid-cancer
MEN2B is a genetic syndrome caused by the RET p.M918T mutation requiring prophylactic thyroidectomy within the first year of life. This single-center study of 6 children with sporadic MEN2B found that despite exhibiting the complete, distinctive phenotype (marfanoid habitus, mucosal neuromas,…
lung-cancer
This population-based case-control study from Northern Ireland is the first UK study to link a nationwide indicative radon atlas with lung cancer risk. 1,687 lung cancer cases (2006, 2014) were compared to 8,094 controls, with radon exposure classified by an atlas categorizing 1 km² areas.
blood-cancer
The bone marrow microenvironment protects leukemia cells from both chemotherapy and immunotherapy, inhibiting T cell infiltration. This study addressed this by engineering CD33-targeted CAR-T cells to express constitutively active Rac1 (Rac1V12)—a GTPase that controls cell migration and tissue…
ovarian-cancer
Few environmental risk factors for ovarian cancer are known. This prospective study of 127,547 postmenopausal women in the Women's Health Initiative followed participants for up to 31 years, linking residential radon zone data to ovarian cancer incidence and mortality.
colorectal-cancer
People living in persistent poverty areas—where 20%+ have been poor for 30+ years—have higher colorectal cancer mortality. This large study of 5,028 Arkansas CRC patients linked registry, death certificate, and insurance claims data to identify what specifically drives this disparity.
blood-cancer
Pediatric ALL survival rates are 80% in Argentina but below 60% in neighboring Paraguay, Peru, and Bolivia—driving medical migration. This retrospective study of 106 migrant children with ALL at a major Argentine center found stark disparities.
colorectal-cancer
CA19-9/albumin ratio (cutoff 5.81) independently predicted shorter PFS (9.6 vs. 16.1 months) and OS (23.3 vs. 32.6 months) in 178 de novo mCRC patients starting standard chemotherapy + biologics. The ratio simultaneously reflects tumor burden (CA19-9) and host nutritional status (albumin), both…
brain-cancer
Using GEO database gene expression profiles and the FerrDb ferroptosis gene database, 10 hub genes were identified in glioma: TP53, RRM2, EZH2, CDKN1A, MYCN, KIF20A, BLM, GLS2, HMOX1, and GOT1. Ferroptosis linked to p53 signaling, apoptosis, and immune regulation. Molecular docking confirmed good…
breast-cancer
Retrospective Chinese study of 318 women with stage I-III HR+ breast cancer: early structured psychological care (≥3 sessions within 3 months of surgery) was associated with significantly better 1-year endocrine therapy adherence (OR 2.15) vs. no/minimal care. Good adherence: 77% (early structured)…
colorectal-cancer
GBD 2021 data analysis (1990-2021, 204 countries) found gastric cancer ASIR and ASMR declined globally, especially in high-SDI countries. Colorectal cancer showed rising ASIR and prevalence but declining ASMR. Males had higher burden for both. Projections suggest gastric cancer to continue…
breast-cancer
Patient samples from a Phase II neoadjuvant talazoparib trial (NCT03499353) revealed two resistance mechanisms: (1) BRN2 overexpression activating ATR/RAD51 and STAT3 pathways to restore HR repair (reversible with ATR and STAT3 inhibitors); (2) pre-existing SHLD2-deficient tumor subclone expansion.…
