melanoma
Three clinical features identify thin melanomas at high risk of recurring within two years: age over 65, ulceration, and mitotic rate Thin melanomas — classified as T1, meaning the tumor is ≤1mm deep — are generally considered low-risk and treated with surgery alone. Yet thin melanomas account for more than 25% of
pancreatic-cancer
Blood test using tumor DNA epigenetics can non-invasively classify pancreatic cancer subtypes that predict treatment response Pancreatic cancer (PDAC) comes in two major subtypes — classical and basal-like — that have very different prognoses and respond differently to chemotherapy and RAS inhibitors. Until now, determining subtype required a tissue biopsy, which is
other-cancer
Improved statistical method for early cancer drug trials better identifies safe and active doses while protecting patients Early-phase (Phase I) cancer trials are designed primarily to find the maximum tolerated dose of a new drug. But the FDA's Project Optimus initiative has pushed for reform, recognizing that the
brain-cancer
New lab model tracks how glioblastoma evolves resistance to chemo and radiation separately, revealing distinct escape routes Glioblastoma almost always comes back after treatment, and recurrent GBM is almost always fatal. A major obstacle to understanding why has been the lack of matched models — lab systems that let you compare
brain-cancer
Nanobody targeting immune protein HVEM suppresses the most treatment-resistant form of glioblastoma in mice Glioblastoma (GBM) is one of the most lethal cancers, and its mesenchymal subtype — characterized by inflammation and resistance to standard therapy — is particularly hard to treat. Researchers found that a protein called HVEM (herpes virus entry
breast-cancer
Protein FILIP1L acts as a metastasis coordinator in breast cancer, linking cell division timing to invasive behavior Cancer cells invade surrounding tissue using specialized structures called invadopodia — spiky protrusions armed with enzymes that chew through the extracellular matrix. Researchers discovered that when breast cancer cells undergo epithelial-to-mesenchymal transition (EMT, the
other-cancer
New tool lets doctors and researchers query a cancer mutation database using plain English through AI chatbots The Clinical Interpretation of Variants in Cancer (CIViC) database is a community-curated resource that links specific genetic mutations to their clinical significance in cancer — what they mean for treatment, prognosis, and drug response.
liver-cancer
Saffron compound crocin kills liver cancer cells by disrupting the RNA splicing machinery Hepatocellular carcinoma (HCC) — primary liver cancer — is notoriously hard to treat. Researchers looked at crocin, the active compound in saffron, to understand how it fights HCC at the molecular level using time-series gene expression analysis at multiple
blood-cancer
Repurposed cancer drug OTS167 targets newly discovered mitotic kinase in aggressive lymphoma, showing tumor reduction in mice Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma, and many patients aren't cured by standard treatment. Researchers screened a library of kinase inhibitors and stumbled onto an unexpected target:
test
news
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