Dan Manning - Cancer News (Page 18)

colorectal-cancer

mRNA-delivered fusion protein combines immune activation and direct cell killing for a new approach to cancer gene therapy

mRNA-delivered fusion protein combines immune activation and direct cell killing for a new approach to cancer gene therapy mRNA-based cancer therapeutics are an emerging area, building on the success of mRNA vaccines. This study engineered a novel fusion protein combining interferon-gamma (IFN-γ) — which activates immune responses — with the intracellular domain

other-cancer

AI trained on spatial tumor images can distinguish between immune structures that help versus hurt cancer outcomes

AI trained on spatial tumor images can distinguish between immune structures that help versus hurt cancer outcomes Tertiary lymphoid structures (TLS) are organized immune cell aggregates that form within tumors, and they're attracting enormous clinical attention — immunogenic TLS correlate with better outcomes and checkpoint therapy response, while tolerogenic

breast-cancer

Multiple versions of a single RNA molecule control cancer cell division and p53 signaling in distinct ways

Multiple versions of a single RNA molecule control cancer cell division and p53 signaling in distinct ways Long non-coding RNAs (lncRNAs) don't encode proteins but profoundly shape gene regulation, and many are highly expressed in aggressive cancers. MANCR is one such lncRNA, highly active in triple-negative breast cancer

colorectal-cancer

Oral pill boosts immune response to colon cancer and supercharges checkpoint immunotherapy

Oral pill boosts immune response to colon cancer and supercharges checkpoint immunotherapy CD4+ helper T cells are critical for enabling CD8 killer T cells to destroy tumors, but tumors frequently suppress them. Alphataxin is an orally available small molecule that mimics alpha-1 antitrypsin, previously shown to elevate CD4+ T cell

breast-cancer

Obesity-driven fat cell signals reshape triple-negative breast cancer's metabolism and gene activity to boost survival

Obesity-driven fat cell signals reshape triple-negative breast cancer's metabolism and gene activity to boost survival Obesity significantly increases triple-negative breast cancer (TNBC) risk and worsens outcomes, but the molecular mechanisms have been unclear. This study examined how signals secreted by fat cells (the adipocyte secretome) reprogram TNBC cells

lung-cancer

One tissue section can now do the diagnostic work of many in lung cancer — saving scarce biopsy material

One tissue section can now do the diagnostic work of many in lung cancer — saving scarce biopsy material Lung cancer diagnosis requires multiple rounds of immunohistochemistry (IHC) to classify tumor type, predict drug sensitivity, and guide treatment. Each test uses part of the biopsy, and small samples — common in lung

colorectal-cancer

A next-generation fluoropyrimidine beats 5-FU in resistant colorectal cancer with lower toxicity

A next-generation fluoropyrimidine beats 5-FU in resistant colorectal cancer with lower toxicity 5-FU (fluorouracil) is still the backbone of colorectal cancer chemotherapy, but resistance is common and side effects are severe. This study introduces CF10, a polymeric version of a fluoropyrimidine designed to deliver the active drug (FdUMP) more sustainably

pancreatic-cancer

Repeated tumor ablation trains the immune system to attack pancreatic cancer — and reveals a targetable brake

Repeated tumor ablation trains the immune system to attack pancreatic cancer — and reveals a targetable brake Thermal ablation (using heat to destroy tumors) is gaining use in pancreatic cancer, but it has mostly been viewed as a local treatment. This study tested whether repeated radiofrequency ablation could trigger a systemic

lung-cancer

Molecular subtype of small cell lung cancer predicts and drives resistance to a newly approved immunotherapy

Molecular subtype of small cell lung cancer predicts and drives resistance to a newly approved immunotherapy Small cell lung cancer (SCLC) is one of the most aggressive cancers, and new treatment options have been desperately needed. Tarlatamab — a bispecific T-cell engager targeting DLL3 — was recently approved for relapsed SCLC, representing

pancreatic-cancer

Newly identified cancer-associated fibroblast subtype could predict who responds to pancreatic cancer treatment

Newly identified cancer-associated fibroblast subtype could predict who responds to pancreatic cancer treatment Pancreatic ductal adenocarcinoma (PDAC) is notorious for its dense, fibrous tumor stroma — a barrier that blocks drug delivery and suppresses immune responses. Within this stroma, cancer-associated fibroblasts (CAFs) play complex, sometimes opposing roles. Using single-cell RNA sequencing

other-cancer

Six Src inhibitors tested in mouth cancer reveal why monotherapy keeps failing — and how to fix it

Six Src inhibitors tested in mouth cancer reveal why monotherapy keeps failing — and how to fix it Oral squamous cell carcinoma (OSCC) is a deadly head and neck cancer with limited systemic treatment options. The kinase Src sits at the intersection of multiple cancer-driving pathways and has long been a

ovarian-cancer

Platinum-resistant ovarian cancer may be vulnerable to a microRNA-driven XIAP suppression strategy

Platinum-resistant ovarian cancer may be vulnerable to a microRNA-driven XIAP suppression strategy High-grade serous ovarian cancer (HGSOC) kills largely because it develops resistance to platinum-based chemotherapy. A core feature of resistant tumors is that cancer cells refuse to die even when chemotherapy signals are present. This study examined whether a