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Pre-treatment MRI features provide independent prognostic information beyond PSA, Gleason grade, and clinical stage in prostate cancer — yet most existing risk calculators don't integrate MRI findings, creating a gap between what imaging tells us and how treatment decisions are made.
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The Physicians Committee for Responsible Medicine has petitioned the USDA to add colon cancer warning labels to processed meats — a science-backed public health intervention supported by WHO Group 1 carcinogen designation that lacks a centralized advocacy coordination resource.
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Post-mastectomy pain syndrome (PMPS) affects a significant subset of mastectomy patients with severe, prolonged neuropathic pain — yet it remains under-recognized, under-treated, and under-studied, partly because patients lack tools to track their symptoms and communicate their experience to…
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Therapy-related AML has tripled over 30 years as more cancer survivors live longer after genotoxic chemotherapy and radiation — yet patients and oncologists rarely have accessible tools to quantify this long-term risk when making treatment decisions or planning survivorship surveillance.
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GLP-1 receptor agonists and bariatric surgery are now proven effective obesity treatments with potential direct anti-cancer effects, but oncology practices and obesity medicine remain siloed — creating a coordination gap for the large fraction of cancer survivors with obesity.
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Elderly patients with prior adenomas face very low absolute colorectal cancer risk relative to competing mortality risks — yet surveillance colonoscopy is still widely recommended as routine, even in patients where the procedure's risks and burdens may outweigh realistic cancer prevention benefits.
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High residential radon was linked to a 30% higher ovarian cancer risk in postmenopausal women — extending radon's known cancer risk beyond lung cancer and providing new evidence that home radon testing has broader cancer prevention relevance for women.
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Large-scale evidence now confirms the 9-valent HPV vaccine cuts cancer risk in males — yet male HPV vaccination rates lag significantly behind female rates in most countries, creating a preventable cancer burden that could be visualized and addressed through data-driven advocacy.
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CA19-9 — the blood test every pancreatic cancer patient gets — is not just a passive indicator of disease; it actively promotes liver metastasis by helping tumor cells stick to liver blood vessels via E-selectin. This mechanistic insight has immediate implications for how patients and clinicians…
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Patient-derived organoids that faithfully recapitulate keratinizing squamous cell carcinoma histology — including spontaneous keratin pearl formation — fill a critical gap in LUSC preclinical modeling, but these rare models are scattered across individual labs with no shared registry.
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Neurosphere cultures from different regions of the same GBM tumor show completely different drug sensitivities, yet standard drug screening uses single-biopsy cell lines — meaning published drug sensitivity data for GBM may be systematically misleading about what would work in the whole tumor.
project-idea
Common cold virus antibodies accidentally target hepatocellular carcinoma via molecular mimicry with ASPH — revealing that prior viral infection history may create natural cancer protection and that viral epitopes could be engineered into therapeutic cancer vaccines.
